Medical Posterous

Medical Posterous

Thilini Mahaliyana  //  Thilini Mahaliyana is a surgical senior resident working in NSW who likes to read and think about the applications of physiology and evidence based medicine in everyday practice

 
Aug 21 / 11:09pm

Life expectancy vs Education Human Development Index

by Sniper Girl

In the 80's life expectancy is well correlated with years spent at school. What happens by 2010? HIV/AIDS and the "war on terror"

 
Aug 21 / 5:07pm

Global Pandemics by Size

by Sniper Girl

The only problem with this one of course is that they use the term "virus" to mean "pathogen". Just ignore the "virus" bit- plague isn't caused by a virus.

Pandemics

 
May 8 / 12:30am

Gonorrhoea & Syphilis rates in the US, by state 1984-2008

by Sniper Girl

  • Chlamydia was not chosen because interestingly its rate is similar throughout the US
  • The southeast has the most issues
  • DC got major issues
  • Evidently people in the mid-west are so sparse that there is no way in hell they can mate
  • Data courtesy of the CDC
Filed under  //  US   USA   bacteria   epidemiology   geography   gonorrhoea   infectious diseases   neisseria gonorrhoeae   sexually transmitted disease   sexually transmitted infection   std   sti   syphilis   treponema pallidum   united states   united states of america  
 
May 3 / 12:10am

Breast Cancer - Invasive Ductal Carcinoma of No Special Type

by Sniper Girl

Immunohistochemistry and phenotypes:

Idc_of_nst

  • Luminal A: generally more favourable prognosis; hormone receptor positive therefore also sensitive to tamoxifen, aromatase inhibitors and other hormonal treatments
  • Luminal B: not quite as good as Luminal A; treatable with both Herceptin and hormonal treatments
  • HER2+ only: most aggressive phenotype- however can be treated with Herceptin (transtuzumab), a HER2 monoclonal antibody
  • Basal-like: a subset of "triple negative" (ie oestrogen & progesterone receptor negative and HER2 negative) cancers. Since the advent of Herceptin, prognosis is worse than for HER2+ tumours.
Filed under  //  ai   allele   aromatase inhibitor   breast cancer   cancer   ck5   ck5/6   ck6   cytokeratin 5   cytokeratin 5/6   cytokeratin 6   eGFR   epidermal growth factor   er   estrogen receptor   genetic   genotype   her2   herceptin   hormonal therapy   hormone   hormone recepter   hormone receptor   idc   immunohistochemistry   imprinting   invasive ductal carcinoma   monoclonal antibody   oestrogen receptor   oncogene   oncogenetic   oncology   phenotype   pr   progesterone receptor   prognosis   receptor   staining   tamoxifen   transtuzumab   tumor   tumor suppressor gene   tumour   tumour suppressor gene  
 
Apr 16 / 11:39pm

Fructose, Uric Acid, Hypertension

by Sniper Girl

In a pretty brilliant application of basic biochemistry to human physiology, Joel Topf (nephrologist) talks about the links between fructose consumption and the epidemic of hypertension, obesity, diabetes and gout.

Filed under  //  HFCS   disaccharide   fructose   fructose metabolism   glucose   gout   high blood pressure   high fructose corn syrup   hyperglycaemia   hyperglycemia   hypertension   krebs cycle   sucrose   urate   uric acid